NUMB3RSisadramaaboutFBIagentDonEppes(RobMorrow),whorecruitshismathematical-geniusbrother,Charlie(DavidKrumholtz)tohelptheBureausolveawiderangeofchallengingcrimesinLosAngeles.Thetwobrotherstakeonthemostconfoundingcriminalcasesfromaverydistinctiveperspective. Inspiredbyactualcases,theseriesdepictshowtheconfluenceofpoliceworkandmathematicsprovidesunexpectedrevelationsandanswerstothemostperplexingcriminalquestions. AdedicatedFBIagent,Doncouldn'tbemoredifferentfromhisyoungerbrother,Charlie,abrilliantmathematicianwho,sincehewaslittle,hasyearnedtoimpresshisbigbrother.Asaseasonedinvestigator,Dondealsinhardfactsandevidence,whereasCharlie,amathprofessorataCaliforniauniversity,functionsinaworldofmathematicalprobabilityandequations. Now,despitetheirdisparateapproachestolife,DonandCharlieareabletocombinetheirareasofexpertiseandsolvesomekillercases.